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Circumcision
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EMLA cream, containing 2.5% lidocaine and 2.5% prilocaine, attenuates the pain response to circumcision when applied 60to 90minutes before the procedure. Compared with placebo groups, neonates who had EMLA cream applied spend less time crying and have smaller increases in heart rate during circumcisions.41-43 The analgesic effect is limited during the phases associated with extensive tissue trauma such as during lysis of adhesions and tightening of the clamp.42,43
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