LYCOS RETRIEVER 
Ciprofloxacin: Joints
built 605 days ago
Ciprofloxacin can cause photosensitivity reactions and can elevate plasma theophylline levels to toxic values. It can ... cause constipation and sensitivity to caffeine. Ciprofloxacin is also known to cause swelling of joints and cartilage, and cause tendon rupture and chronic pain.
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Ciprofloxacin and other quinolones have been shown to cause arthropathy in immature animals of most species tested (See WARNINGS). Damage of weight bearing joints was observed in juvenile dogs and rats. In young beagles 100 mg/kg ciprofloxacin given daily for 4 weeks, caused degenerative articular changes of the knee joint. At 30 mg/kg the effect on the joint was minimal. In a subsequent study in beagles removal of weight bearing from the joint reduced the lesions but did not totally prevent them.
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Ciprofloxacin is endured very well. Seldom are observed the following side effects: gastro-intestinal disorders (nausea, emesis, diarrhea, pains and hooves, lack of appetite); manifestations of neurotoxicity (vertigo, cephalalgia (headache), excitation, fright condition, violation of the periphere sensibility and very rarely double vision, changes in the color reception, convulsions; allergy reactions (irritation, exanthema, erythema, medicine fever, edema of the face; cardiovascular disorders (hypotension, tachycardia; pains in the joint; fleeting changes of the laboratory indices – increase of the transminases, the alkaline phosphates, the bilirubin, urea, creatinine, cristalluria (if no sufficient quantity of liquids are taken). In individual cases some other phenomena are possible, described in the application of the preparation of the chinolone group: changes in blood condition, tongue edema, swallowing embarrassment, asthma, fulminating shock, papulas, hemorrhagic bullos, vasculitis, intensified heat (erubescense of the skin) after durable isolating, etc.
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