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Ciprofloxacin: Drug Administration
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Ciprofloxacin is excreted in human milk. The amount of ciprofloxacin absorbed by the nursing infant is unknown. Because of the potential for serious adverse reactions in infants nursing from mothers taking ciprofloxacin, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
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Ciprofloxacin is a synthetic broad spectrum antibacterial agent for oral administration. Ciprofloxacin, a fluoroquinolone, is available as the monohydrochloride monohydrate salt of 1-cyclopropyl-6-fluoro-1, 4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid. It is a faintly yellowish to light yellow crystalline substance with a molecular weight of 385.8. Its empirical formula is C17H18FN3O3.HCl.H2O.
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Ciprofloxacin is indicated in pediatric patients for inhalational anthrax (post-exposure). The risk-benefit assessment indicates that administration of ciprofloxacin to pediatric patients is appropriate. For information regarding pediatric dosing in inhalational anthrax (post-exposure), see DOSAGE AND ADMINISTRATION and INHALATIONAL ANTHRAX — ADDITIONAL INFORMATION.
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Ciprofloxacin has been reported to cause cartilage damage to the foetus in animal studies. Alternatives are rifampicin and ceftriaxone but rifampicin ... FDA risk factor C for pregnancy thus avoid. Use Ceftriaxone 250mg im single dose ; Alternative drugs to Ceftriaxone, e.g. Cefotaxime or benzyl penicillin + chloramphenicol, or cefotaxime plus ampicillin.
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