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Cimetidine
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Cimetidine is prescribed for the treatment of certain kinds of stomach and intestinal ulcers and related conditions. These include: active duodenal (upper intestinal) ulcers; active benign stomach ulcers; erosive gastroesophageal reflux disease (backflow of acid stomach contents); prevention of upper abdominal bleeding in those who are critically ill; and excess-acid conditions such as Zollinger-Ellison syndrome (a form of peptic ulcer with too much acid). It is ... used for maintenance therapy of duodenal ulcer following the healing of active ulcers. Cimetidine is known as a histamine blocker. Some doctors also use Cimetidine to treat acne and to prevent stress-induced ulcers. It may also be used to treat chronic hives, herpesvirus infections (including shingles), abnormal hair growth in women, and overactivity of the parathyroid gland.
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Cimetidine is both metabolized in the liver and excreted unchanged by the kidneys. More drug is excreted by the kidneys when administered parenterally (75%) than when given orally (48%). The average serum half-life is 2 hours in humans, but can be prolonged in elderly patients and in those with renal or hepatic disease. Peritoneal dialysis does not appreciably enhance the removal of cimetidine from the body.
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Cimetidine may reduce vitamin D activation by the liver.4 Lab tests can measure activated vitamin D levels in the blood. Forms of vitamin D that do not require liver activation are available, but only by prescription.
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Cimetidine may cause dizziness or drowsiness. These effects may be worse if you take it with alcohol or certain medicines. Use Cimetidine with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
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Cimetidine may decrease the renal clearance of procainamide. Cimetidine may exacerbate leukopenias when used with other agents that can cause this problem. Stagger doses (separate by 2 hours if possible) of cimetidine with antacids, metoclopramide, sucralfate, digoxin, and ketoconazole.
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