LYCOS RETRIEVER 
Cimetidine: Studies
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Cimetidine crosses the placental barrier and can cross the blood-brain barrier. Animal studies have not indicated any incidence of mutagenicity, carcinogenicity or teratogenicity on the foetus. Cimetidine should be avoided in pregnancy unless the benefits outweigh the potential risk to the foetus. Cimetidine has been used in clinical trails for the prevention of acid aspiration pneumonitis in women undergoing caesarean section or vaginal delivery without harm.
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Cimetidine has demonstrated a weak antiandrogenic effect. In animal studies this was manifested as reduced prostate and seminal vesicle weights. However, there was no impairment of mating performance or fertility, nor any harm to the fetus in these animals at doses 8 to 48 times the full therapeutic dose of Cimetidine, as compared with controls. The cases of gynecomastia seen in patients treated for 1 month or longer may be related to this effect.
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Cimetidine, approved by the FDA for inhibition of gastric acid secretion, has been advocated for a number of dermatological diseases. The cutaneous uses and immunological effects of cimetidine have been actively studied over the past few years, and this review summarizes the literature accumulated since 1997.
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Cimetidine may ... fight cancer by promoting apoptosis (programmed cell death) in cancer cells. In a Chinese study from 2006, cimetidine induced apoptosis and halted cell division in human gastric cancer cells, leading the researchers to propose that cimetidine may have applications in treating gastric cancer.26
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Reversible impotence has been reported in patients with pathological hypersecretory disorders, e.g., Zollinger-Ellison Syndrome, receiving Cimetidine, particularly in high doses, for at least 12 months (range 12 to 79 months, mean 38 months). However, in large-scale surveillance studies at regular dosage, the incidence has not exceeded that commonly reported in the general population.
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