LYCOS RETRIEVER 
Cimetidine: Histamine
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Cimetidine is a histamine H2-receptor antagonist. Chemically it is N''-cyano-N-methyl-N'-(2-(((5-methyl-1 H-imidazol-4-yl)methyl)thio)- ethyl) guanidine. The empirical formula for cimetidine is C10H16N6S and for cimetidine hydrochloride, C10H16N6SHCl; these represent molecular weights of 252.34 and 288.80, respectively. Cimetidine contains an imidazole ring, and is chemically related to histamine. Cimetidine has a bitter taste and characteristic odor.
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Cimetidine is a histamine H2-receptor antagonist which competitively inhibits the action of histamine on the H2-receptors of parietal cells. Gastric output is reduced under basal conditions and ... when stimulated by food, insulin, betazole, histamine, pentagastrin and caffeine. Pepsin output is indirectly reduced because of the decreased amount of gastric juice.
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Cimetidine was useful in treating pruritus after a burn injury. In a study controlling for the effect of topical medications, a cetirizine-cimetidine combination demonstrated a dramatic improvement at 1 and 6 hours, and a moderate improvement at 12 hours after the initial administration of the medication when compared with a diphenhydramine-placebo combination.[45] Oral cimetidine accelerated the recovery of skin barrier function after disruption in a dry environment, but histamine and the histamine H2 receptor agonist, dimaprit, delayed barrier repair.[46]
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Cimetidine's beneficial effects in helping to manage various cancers are well documented. For more than 20 years, scientists have accumulated evidence that this low-cost, readily available heartburn remedy fights cancer via several mechanisms of action, including blocking the immunosuppressive action of histamine, modulating the body's immune response, inhibiting angiogenesis, stimulating cancer cell death, and inhibiting cancer metastasis.
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Cimetidine is not an anticholinergic agent. Studies have shown that Cimetidine inhibits both daytime and nocturnal basal gastric acid secretion. Cimetidine ... inhibits gastric acid secretion stimulated by food, histamine, pentagastrin, caffeine and insulin.
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