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Cimetidine: Drugs
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Cimetidine is metabolized at a certain place in the liver where many other drugs are ... broken down. So there are potential interactions with many other drugs. However, in clinical practice, physicians have seen remarkably few problems. Still, if you take any of the following, you should check with your physician.
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Cimetidine (INN) is a histamine H2-receptor antagonist that inhibits the production of acid in the stomach. It is largely used in the treatment of heartburn and peptic ulcers. It is marketed by GlaxoSmithKline under the trade name Tagamet® (sometimes Tagamet HB® or Tagamet HB200®) and was approved by the Food & Drug Administration for prescriptions starting January 1, 1979.
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Cimetidine is a competitive inhibitor of histamine at the histamine H2 receptors of the parietal cells, and ... is known as a histamine antagonist. These drugs are used to treat gastric and duodenal ulcers by inhibition of gastric acid secretion stimulated by food, insulin, histamine, caffeine, and pentagastrin. Cimetidine is also helpful in treating upper gastrointestinal bleeding in critically ill patients. Side effects include skin rash, confusion, irregular heartbeat, and sore throat.
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DRUG CLASS AND MECHANISM: Cimetidine belongs to a class of medications called histamine H2-antagonists. Histamine is a natural chemical that stimulates stomach cells to produce acid. Histamine H2-antagonists inhibit the action of histamine on the acid-producing cells of the stomach and reduce stomach acid. Cimetidine was approved by the FDA in 1977.
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Cimetidine is a member of the H-2 blocker (histamine blocker) family of drugs that prevents the release of acid into the stomach. Cimetidine is used to treat stomach and duodenal ulcers, reflux of stomach acid into the esophagus, and Zollinger-Ellison syndrome. Cimetidine is available as a prescription drug and as a nonprescription over-the-counter product for relief of heartburn.
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Cimetidine is a known inhibitor of many isozymes of the cytochrome P450 enzyme system (specifically CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP2E1, and CYP3A4). This inhibition forms the basis of the numerous drug interactions that occur between cimetidine and other drugs. For example, cimetidine may decrease metabolism of some drugs, such as oral contraceptives.
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