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Celexa
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Celexa is the newest antidepressant to be approved by the FDA. It is the most selectively acting on serotonin of the selective serotonin reuptake inhibitors (SSRI). It has been used in Europe for almost a decade, and a total of 8 million patients have been prescribed Celexa. It has many similarities to the other SSRI's-Prozac, Zoloft, Paxil, and Luvox. Like any antidepressant, not everyone responds or tolerates any given medication. Treatment must always be individualized.
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Celexa is the brand name. Citalopram is the generic name. Celexa is a selective serotonin reuptake inhibitor (SSRI) used to treat depression.SSRI medications affect the levels of serotonin in the brain. For many people, these medications are the first choice for the treatment of depression. For information on SSRIs and how they work, see SSRIs and Depression.
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Forest Laboratories, the manufacturer of Celexa, has developed the next generation of Celexa, called Lexapro, which can treat both depression and generalized anxiety disorder (GAD). Lexapro has proven advantages over Celexa that provide people with better symptom relief and better tolerability. In fact, 47% of patients who did not respond to Celexa treatment responded to treatment with Lexapro.1,2 If you would like to learn more about Lexapro, visit Lexapro.com.
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Celexa has helped patients find relief from depression for years now. Celexa helps to restore the brain's chemical balance by increasing the supply of a chemical messenger in the brain called serotonin. Because Celexa appears to relieve depression by increasing serotonin with minimal effect on many of the other chemicals in the brain, Celexa may cause relatively few and mild side effects, which tend to go away with continued treatment. Order Celexa today and receive a FREE consultation - a $49 value absolutely free!
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Celexa is not appropriate for everyone. A thorough medical history should be evaluated prior to prescribing this medication. Patients with a medical history that includes seizures, epilepsy, liver disease, kidney disease, bipolar disorder, suicidal tendencies, or drug abuse should not take Celexa. Celexa may cause suicidal thoughts or ideation. Patients who have taken an MAO inhibitor within 14 days of starting or stopping Celexa run a serious risk of serious health problems including coma and death.
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The efficacy of Celexa as a treatment for depression was established in two placebo-controlled studies (of 4 to 6 weeks in duration) in adult outpatients (ages 18-66) meeting DSM-III or DSM-III-R criteria for major depression. Study 1, a 6-week trial in which patients received fixed Celexa doses of 10, 20, 40, and 60 mg/day, showed that Celexa at doses of 40 and 60 mg/day was effective as measured by the Hamilton Depression Rating Scale (HAMD) total score, the HAMD depressed mood item (Item 1), the Montgomery Asberg Depression Rating Scale, and the Clinical Global Impression (CGI) Severity scale. This study showed no clear effect of the 10 and 20 mg/day doses, and the 60 mg/day dose was not more effective than the 40 mg/day dose. In study 2, a 4-week, placebo-controlled trial in depressed patients, of whom 85% met criteria for melancholia, the initial dose was 20 mg/day, followed by titration to the maximum tolerated dose or a maximum dose of 80 mg/day. Patients treated with Celexa showed significantly greater improvement than placebo patients on the HAMD total score, HAMD item 1, and the CGI Severity score. In three additional placebo-controlled depression trials, the difference in response to treatment between patients receiving Celexa and patients receiving placebo was not statistically significant, possibly due to high spontaneous response rate, smaller sample size, or, in the case of one study, too low a dose.
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