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Celebrex: Studies
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[T]here is much interest lately in the use of Cox-2 inhibitors (such as Celebrex), the anti-inflammatory drug recalled not long ago for its adverse side effects. A recent study showed a "dramatic" reduction in adhesions in mice treated with Cox-2 inhibitors. According to a press release, investigators Dr. Mark Puder and Dr. Arin Greene from Boston's Children's Hospital are preparing to set up a clinical trial of Celebrex in adult surgical patients.
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A recent study has shown that patients who take this medication may be in serious Celebrex danger. The National Cancer Institute discovered this Celebrex danger while studying the effects of Celebrex on the formation of colon polyps. This clinical trial was designed as a three year study to measure the long term colorectal effects of Celebrex as compared to a placebo, or dummy pill. This clinical trial was sponsored in part by Pfizer, the makers of this top selling prescription medication.
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FitzGerald ... challenged Pfizer's contention that no science shows increased risk from Celebrex. The original report from one study involving Celebrex found no increased risk of heart problems, but it covered only six months of a year-long study, according to the cardiologist.
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Pfizer and the FDA plan further discussions regarding the precise content of the Celebrex label. Pfizer has accumulated extensive Celebrex clinical data over the past 10 years involving more than 40,000 patients. Pfizer ... reaffirmed its commitment to conduct additional long-term clinical studies evaluating the benefits and risks of Celebrex.
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You shouldn't take Celebrex if you have asthma or have had other allergic reactions to aspirin or other NSAIDs. You should ... skip it if you're allergic to sulfa drugs. If you're pregnant, steer clear of Celebrex unless your physician believes that the benefit to you outweighs the possible risk to your baby. In studies on pregnant rats, a dose equivalent to double the daily human dose caused certain birth defects, and higher doses increased the chances of miscarriage.
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Pfizer announced that its painkiller Celebrex puts patients at "increased cardiovascular risk" for heart problems, citing a long-term cancer study. Celebrex is in the same class as Bextra and Vioxx, which was pulled from the market in September because of safety concerns.
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