LYCOS RETRIEVER 
Celebrex: Risks
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Like other NSAID medication, Celebrex could increase the chance of having a heart attack or stroke, possibly resulting in death. The risk is greater if you have heart disease or use NSAIDs for a long time. It's important to discuss the risks and benefits of using Celebrex with your doctor and to use the lowest effective dose for the shortest amount of time possible.
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The worrisome results came from a clinical trial being conducted by the National Cancer Institute into whether Celebrex might protect people at risk of colorectal cancer. Ernest Hawk, chief of gastrointestinal research for NCI, said a team of cardiovascular specialists had been brought in to help analyze the cardiovascular risk of Celebrex for participants in the trial after Vioxx was withdrawn in late September.
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WASHINGTON, DC — August 22, 2005 — The Food and Drug Administration (FDA) has ordered Pfizer to upgrade the label warnings for Celebrex® (celecoxib) to state that the arthritis drug may increase the risk of heart attacks, strokes, and blood clots. Doctors are ... advised that the drug should not be used following coronary bypass surgery, and that it may cause stomach bleeding and ulcers.
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Both rofecoxib (Vioxx) and celecoxib (Celebrex) are selective COX-2 inhibitors. Given an increase in the cardiovascular event rate with rofecoxib (Vioxx) in the Vigor trial, it was of concern in 2001 that there was an increased risk with celecoxib (Celebrex) since these drugs are in the same class of medications.
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According to the complaint, Celebrex ads overstate its safety by saying that it provides effective pain relief without the side effects inherent to similar drugs. The misleading ads drove the demand and price of Celebrex beyond what it would have been, had Pfizer truthfully disclosed the drug's risks, the suit states.
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In the recent highlighted study of Celebrex at 4 times usual dose in bowel cancer / bowel polyp study a slight risk was noted after 15 months use. In another identical group NO risk was found. No other Celebrex study really shows risk.
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