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Celebrex: Drugs
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Like Vioxx, Celebrex is a Cox-2 inhibitor approved by the US Food and Drug Administration (FDA) on December 31, 1998 for the treatment of rheumatoid arthritis and osteo-arthritis. Recent studies in the wake of Vioxx implications conclude possible heart attacks and stroke for patients using any Cox-2 inhibitor drugs. Doctors are advising patients with heart disease not to use drugs such as Celebrex.
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As mentioned, Celebrex is part of a class of NSAIDs called COX-2 inhibitors. The drug works by blocking a particular enzyme (COX-2) that plays a role in pain and inflammation. Unlike other NSAIDs (such as ibuprofen and naproxen) that target both the COX-1 and the COX-2 enzymes, Celebrex only targets the COX-2 enzyme. The COX-1 enzyme plays an important role in protecting the lining of the stomach.
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Celebrex, Bextra (... a Pfizer product) and Vioxx, made by Merck & Co., are all COX-2 anti-inflammatory drugs. Merck withdrew Vioxx from the market after its own study showed that Vioxx patients suffered roughly twice the number of heart attacks and strokes. A deluge of lawsuits followed the drug’s withdrawal by people who claim to have suffered severe heart attacks and stroke, many of them represented by Kline & Specter.
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After the withdrawal of rofecoxib (Vioxx) from the market in September 2004, Celebrex enjoyed a robust increase in sales. However, the results of the APC trial in December of that year raised concerns that Celebrex might carry risks similar to those of Vioxx, and Pfizer announced a moratorium on direct-to-consumer advertising of Celebrex soon afterwards. After a significant drop, sales of Celebrex have recovered, and reached $2 billion in 2006.[2] Pfizer resumed advertising Celebrex in magazines in 2006,[10] and resumed television advertising in April of 2007 with an unorthodox, 2 1/2 minute advertisement which extensively discussed the adverse effects of Celebrex in comparison to other anti-inflammatory drugs. The ad drew criticism from the consumer advocacy group Public Citizen, which called the ad's comparisons misleading.[11] Pfizer has responded to Public Citizens concerns with assurances that they are truthfully advertising the risk and benefits of Celebrex as set forth by the FDA.
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Besides producing Celebrex®, Pfizer manufactures another arthritis drug and COX–2 inhibitor, Bextra® (valdecoxib). A recent warning on the Bextra® label states that patients who have undergone heart bypass surgery should not take the drug because it increases their risk of additional heart problems. Bextra® may ... cause a severe allergic skin reaction known as Stevens–Johnson syndrome in some users. See Bextra® Label Updated for more information.
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