LYCOS RETRIEVER 
Celebrex: Cox-2
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Celebrex is the first of a new class of drugs called COX-2 inhibitors, often promoted as "super-aspirins." By selectively blocking only COX-2, they are somewhat easier on the stomach than most anti-inflammatory medications.
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Celebrex inhibits a key enzyme, called COX-2, that's on cell pathways leading to inflammation. COX-2 is ... involved, though indirectly, in release of the neurotransmitter glutamate from astrocytes, cells in the nervous system that support nerve cell function. In excess, glutamate is toxic to neurons and other cells. Scientists recognize this "excitotoxicity" as a major destructive process in ALS.
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Celebrex (generic name celecoxib), is a long-awaited treatment option for people suffering with arthritis. Celebrex is the first FDA approved medication in a new class of arthritis drugs known as COX-2 selective inhibitors.
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Celebrex, a COX-2 inhibitor that is usually prescribed for arthritis, has shown an effect on mice who have malignant mesothelioma. Celebrex (celecoxib) has shown to inhibit mesothelioma cells while not affecting the growth of normal mesothelial cells along the lung lining.
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Pfizer Inc announced today that 17 European countries agreed to extend the Celebrex (celecoxib capsules) label to include symptomatic relief in the treatment of ankylosing spondylitis (in adults), a form of arthritis that affects the spine. Once each country updates its labeling, Celebrex will be the first oral selective COX-2 inhibitor available in Europe to treat this chronic and debilitating condition.
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Toxic epidermal necrolysis is believed to be an allergic reaction to drugs in the NSAID family, like Bextra & Celebrex. Bextra (valdecoxib) and Celebrex (celecoxib) are COX-2 inhibitor drugs that have been known to illicit SJS and/or TEN. Toxic epidermal necrolysis has been classified as an immunological disorder.
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