LYCOS RETRIEVER 
Carpal Tunnel Syndrome: People
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Researchers have discovered that prostaglandin-2, vascular endothelial growth factor, and interluekin-6 are all elevated in the carpal tunnel tissue of people with CTS. These inflammatory factors act directly on tissue by increasing the ability of fluids and small molecules to cross from the blood into the tissue itself, and they may stimulate the growth of fibroblasts, which are responsible for forming scar tissue (Kuhn MA et al 2002). However, levels of interleukin-1, a pro-inflammatory chemical, are the same in people with CTS and people without the condition, which implies that those with CTS do not have a full-blown, systemic inflammatory response. Instead, evidence suggests that the underlying cause of CTS may be an increase in specific local inflammatory factors in response to mechanical stress that causes increased vascular permeability and perfusion (or movement of fluid through the tissues of the carpal tunnel), which leads to the deposition of scar tissue (fibrosis) that characterizes CTS (Bland JD 2005; Hirata H et al 2004; Freeland AE et al 2002; Tucci MA et al 1997).
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Broken or dislocated wrist bones or even sprains that cause swelling around the carpal tunnel may lead to CTS, too. Medical problems that increase someone's risk of getting CTS include arthritis, thyroid problems, and diabetes. CTS is ... more common during pregnancy and in people who are overweight.
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The nerve compression associated with CTS is due to fibrous bands of tissue that form inside the carpal tunnel, squeezing the median nerve. Although CTS is linked to repetitive stress, the underlying cause—which would explain why some people suffer from it and others don't—is unknown. Newer research has uncovered some of the chemical changes that occur in response to mechanical injury among people who suffer from CTS. Although CTS is technically a noninflammatory condition (because there is no systemic inflammation and the immune system is not activated), it is characterized by localized increases in many pro-inflammatory chemicals in the tissue of the carpal tunnel itself.
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This article explains what carpal tunnel syndrome is and the role physical therapists play in treating this debilitating disease and in educating people about possible risk factors. It ... tells you how you can avoid CTS both at work and at home.
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