LYCOS RETRIEVER 
Carbamazepine: Effects
built 622 days ago
Concomitant administration of Carbamazepine with erythromycin, cimetidine, propoxyphene, isoniazid, fluoxetine or calcium channel blockers has been reported to result in elevated plasma levels of carbamazepine resulting in toxicity in some cases. Also, concomitant administration of carbamazepine and lithium may increase the risk of neurotoxic side effects.
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Carbamazepine side-effects are usually fatigue, dizziness, and nausea. Occasionally, vomiting occurs. Elderly may get difficulty concentrating, double vision, and staggering (ataxia). Low sodium blood levels may occur with edema and weight gain early symptoms. In less than 1 in 100,000, it may cause aplastic anemia or agranulocytosis. Signs of infections, e.g. unexplained sore throats, should lead to a white blood cell test.
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Carbamazepine is available in many different forms (for example: liquid, tablet, capsule, long–acting). The recommended starting dose of Carbamazepine in adults is 200-400mg daily in 2-4 divided doses. While the usual effective dose of carbamazepine ranges from 200-2000mg/day, your healthcare provider will determine the dose that is right for you based upon your response.
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Carbamazepine passes into breast milk in concentrations of about 25 to 60% of the plasma level. No reports are available on the long-term effect of breast-feeding. The benefits of breast-feeding should be weighed against the possible risks to the infant. Should the mother taking carbamazepine nurse her infant, the infant must be observed for possible adverse reactions, e.g. somnolence.
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Carbamazepine passes into the breast milk (about 25 to 60% of plasma concentrations). The benefits of breast-feeding should be weighed against the remote possibility of adverse effects occurring in the infant. Mothers taking Tegretol may breast-feed their infants, provided the infant is observed for possible adverse reactions (e.g. excessive somnolence, allergic skin reaction).
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Carbamazepine is known to render many hormonal contraception products ineffective, due to its action as a cytochrome P450 enzyme inducer, which is the system that metabolizes many oral contraceptives. Carbamazepine causes more cytochrome P450 enzyme to be produced, which hastens removal of the contraceptive from the blood plasma although the clinical significance of this effect is debatable.
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