LYCOS RETRIEVER 
Carbamazepine: Dose
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Carbamazepine is 76% bound to plasma proteins. Carbamazepine is primarily metabolized in the liver. Cytochrome P450 3A4 was identified as the major isoform responsible for the formation of carbamazepine-10,11-epoxide. Since carbamazepine induces its own metabolism, the half-life is ... variable. Following a single extended- release dose of carbamazepine, the average half-life range from 35-40 hours and 12- 17 hours on repeated dosing. The apparent oral clearance following a single dose was 25 ± 5 mL/min and following multiple dosing was 80 ± 30 mL/min.
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Carbamazepine can cause a decrease in the body’s sodium level, especially at higher doses. Although low sodium levels may not cause observable symptoms, some signs of low sodium include nausea, drowsiness, impaired consciousness, or confusion.
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Carbamazepine is absorbed almost completely but relatively slowly from the tablets. The conventional tablets yield mean peak plasma concentrations of the unchanged substance within 12 and 6 hours, respectively, following single oral doses. With the syrup, mean peak plasma concentrations are attained within 2 hours. With respect to the amount of active substance absorbed, there is no clinically relevant difference between the oral dosage forms. After a single oral dose of 400 mg carbamazepine (tablets) the mean peak concentration of unchanged carbamazepine in the plasma is approx. 4.5 micrograms/mL.
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Carbamazepine has not been studied in pregnant women. There have been reports of babies having low birth weight, small head size, skull and facial defects, underdeveloped fingernails, and delays in growth when their mothers had taken carbamazepine in high doses during pregnancy. Studies in animals have shown that carbamazepine causes birth defects when given in large doses.
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Testicular atrophy occurred in rats receiving Carbamazepine orally from 4 to 52 weeks at dosage levels of 50 to 400 mg/kg/day. Additionally, rats receiving Carbamazepine in the diet for two years at dosage levels of 25, 75, and 250 mg/kg/day had a dose-related incidence of testicular atrophy and aspermatogenesis. In dogs, it produced a brownish discoloration, presumably a metabolite, in the urinary bladder at dosage levels of 50 mg/kg and higher. Relevance of these findings to humans is unknown.
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The number of tablets or capsules prescribed per-day depends on the strength of the prescription drug Generic for Carbamazepine. In addition, the amount of tablets or capsules taken, the time between doses, and the duration the drug is taken is dependant on the medical problem related to the prescription and the discretion of the physician prescribing the drug. Always Follow the instructions given to you by your physician.
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