LYCOS RETRIEVER 
Carbamazepine: Children
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The pharmacokinetic parameters of Carbamazepine disposition are similar in children and in adults. However, there is a poor correlation between plasma concentrations of Carbamazepine and Carbamazepine dose in children. Carbamazepine is more rapidly metabolized to Carbamazepine-10,11-epoxide (a metabolite shown to be equipotent to Carbamazepine as an anticonvulsant in animal screens) in the younger age groups than in adults. In children below the age of 15, there is an inverse relationship between CBZ-E/CBZ ratio and increasing age (in one report from 0.44 in children below the age of 1 year to 0.18 in children between 10-15 years of age).
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Carbamazepine induces its own metabolism, so that the plasma half-life ranges from 18 to 60 hours following a single dose, and from 10 to 35 hours during chronic therapy. The half-life is shorter in children than in adults.
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The evidence assembled was primarily obtained from short-term use of Carbamazepine. The safety of Carbamazepine in children has been systematically studied up to 6 months. No longer-term data from clinical trials is available.
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