LYCOS RETRIEVER 
Betamethasone: Betamethasone Valerate
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Betamethasone mousse is a stabilized foam formulation of betamethasone 17-alpha-valerate, a mid-potency corticosteroid. When applied to the body, betamethasone mousse liquefies and remains localized at the disease site. In addition, the mousse formulation is designed to be easier-to-apply, less messy and cosmetically more acceptable than currently marketed dermatological lotions, creams and ointments.
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Betamethasone has relatively high glucocorticoid activity (anti-inflammatory effects) with insignificant mineralocorticoid activity (effects on the fluid and electrolyte balance). Systemic glucocorticoid effects are described under ADVERSE EFFECTS. The risk of systemic glucocorticoid effects is significantly less with topically administered betamethasone valerate than with the oral administration of the parent compound (betamethasone). It has been estimated the application of more than 100g of 0.1%w/w betamethasone valerate to the skin in one week is likely to cause adrenal suppression. The systemic absorption of betamethasone valerate can occur in situations when it is applied to large areas of the body, thin skin, open lesions, or is covered by an occlusive dressing. Once absorbed through the skin the pharmacokinetics of topical corticosteroids are similar to those of the systemically administered parent compound.
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Betamethasone was originally approved by the FDA in 1961, with a foam-style formulation, called betamethasone valerate, approved in 1999. Betamethasone is a drug in the steroid family of medications, and comes in topical applications. Besides the foam, it can be prescribed as an ointment, cream, lotion, or aerosol spray. Its function is to reduce swelling and to decrease the body’s immune response. This immune response is often what causes painful reactions that result in many different illnesses or disorders. It comes under several different brand names, including Alphatrex, Beta-Val, Betalene, Betratrex, Diprolene, Diprosone, Maxivate, Valisone, Luxiq Foam, and Valnac Topical.
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Betamethasone Valerate