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Beclomethasone
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Beclomethasone 17, 21-dipropionate is a diester of beclomethasone, a synthetic halogenated corticosteroid. Animal studies show that beclomethasone dipropionate has potent anti-inflammatory activity. When beclomethasone dipropionate was administered systemically to mice, the anti-inflammatory activity was accompanied by other features typical of glucocorticoid action, including thymic involution, liver glycogen deposition, and pituitary-adrenal suppression. However, after systemic administration of beclomethasone dipropionate to rats, the anti-inflammatory action was associated with little or no effect on other tests of glucocorticoid activity.
Beclomethasone is for inhalation through the mouth and into the lungs. Follow the directions on the prescription label. As with all inhalers, you should prime the inhaler prior to the first use and in cases where the inhaler has not been used for more than 7—10 days. Prime by 'test-spraying' the inhaler two times into the air, away from the eyes and face.
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JAMA: The Journal Of the American Medical Association.  To Promote the Science and Art of Medicine and the Betterment of the Public Health Beclomethasone dipropionate was administered by aerosol to 30 patients whose chronic bronchial asthma required oral corticosteroid therapy. During the initial 12 weeks of the trial, beclomethasone therapy could be discontinued in 12 of 16 patients in contrast to only one of 14 patients receiving the inert aerosol placebo. Patients receiving the placebo were then given beclomethasone, and prednisone therapy was discontinued in five more. During six months of observation, adrenal function improved and steroid toxic reactions decreased in patients in whom oral corticosteroid therapy had been discontinued. Beclomethasone aerosol was generally well-tolerated. Asymptomatic thrush developed in four patients and rhinitis developed in ten patients as prednisone therapy was discontinued.
Beclomethasone dipropionate aerosol therapy can replace or diminish systemic corticosteroid therapy in the majority of asthmatics. In a clinical trial of 41 patients with perennial asthma, the 10 who had not required long-term corticosteroid therapy improved symptomatically and in pulmonary function. Of the 31 who had required prolonged systemic corticosteroid therapy 12 were able to discontinue oral prednisone therapy, 15 were able to decrease the maintenance dose of prednisone and only 4 were unable to decrease the dose; all maintained satisfactory lung function and some showed improvement. Discontinuation of systemic corticosteroid therapy was accomplished more readily in patients whose daily maintenance dose was less than 15 mg and who had been taking the drug for less than 3 years. Side effects consisted of a "dry throat" in seven patients, two of whom had throat infections with Candida albicans. Recurrence of rhinitis after discontinuation or reduction of systemic corticosteroid therapy was noted in 11 patients.
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Beclomethasone is used to prevent wheezing, shortness of breath, and breathing difficulties caused by severe asthma and other lung diseases. Beclomethasone is in a class of medications called corticosteroids. It works by reducing swelling in the airways.
Source:
Beclomethasone Beclomethasone, a corticosteroid, is used to prevent wheezing, shortness of breath, or troubled breathing caused by asthma or other lung diseases. It will not relieve an asthma attack that has already started.
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