LYCOS RETRIEVER 
Arthritis: Patients
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In the clinical trial, 27 female patients, ranging in age from 29 to 50 years, with mild to moderately severe rheumatoid arthritis, were treated with AVR118 for a period of 90 days. These patients had previously been treated with other anti-inflammatory drugs such as aspirin. By day 90, all patients had either complete regression or significant decrease of joint swelling. Measurements of joint mobility showed improvement in all patients. All patients showed decreases in the level of the erythrocyte sedimentation rate (ESR) by day 90 of therapy and most patients showed decreases in the latex fixation test. There were no significant side effects of AVR118 observed in this study.
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At this time, the only type of arthritis that can be cured is that caused by infections. Although symptoms of other types of arthritis can be effectively managed with rest, exercise, and medication, there are no cures. Some people claim to have been cured by treatment with herbs, oils, chemicals, special diets, radiation, or other products. However, there is no scientific evidence that such treatments are helpful in patients with arthritis and... they may actually cause harm with the development of side effects. Patients should talk to their doctor before using any therapy that has not been prescribed or recommended by the health care team caring for the patient.
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Anti-inflammatory drugs are the main weapon that conventional medical doctors prescribe for chronic inflammatory arthritis. Non-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin, ibupofen, and gold compounds; and steroid-based drugs such as corticosteroids and immuno-suppressive drugs are widely used for arthritis. Long-term use of these medications can produce side effects such as stomach irritation, gastritis and ulcers. An exercise program and physical therapy are helpful for osteoarthritis patients to maintain a satisfactory level of activity. Non-steroidal anti-inflammatory drugs and corticosteroids are provided for short-term relief.
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The most common assistive devices for treating arthritis pain are splints and braces, which are used to support weakened joints or allow them to rest. Some of these devices prevent the joint from moving; others allow some movement. A splint or brace should be used only when recommended by a doctor or therapist, who will show the patient the correct way to put the device on, ensure that it fits properly, and explain when and for how long it should be worn. The incorrect use of a splint or brace can cause joint damage, stiffness, and pain.
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The Phase IIb randomized, double-blind, placebo-controlled clinical trial is designed to enroll 280 patients with rheumatoid arthritis. Patients have been randomized into five groups to evaluate the safety and efficacy of an infused dose of TRU-015 compared to placebo for a 24-week period. Building on the findings of Trubion's Phase IIa clinical trial, this trial will evaluate the effect of a single infusion of TRU-015 ranging from 200 mg to 1,600 mg per patient.
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Glucosamine and Chondroitin sulfate, substances found naturally in the body, have been reported to relieve symptoms of arthritis at a level similar to that of nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen and aspirin. Merck & Co., manufacturer of a popular arthritis medication VIOXX, recently pulled the drug off the market due to reports citing an increased risk of heart attack and stroke among users. Dr. Crawford with the FDA states that, "All of the NSAID drugs have risks when taken chronically, especially of gastrointestinal bleeding, but ... liver and kidney toxicity." Arthritis patients need to be familiar with the various treatment options available and chose one that best suits them.
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