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Arthritis: Diseases
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Over the past decade, advances in inflammatory arthritis drug discovery and development have identified TNF-alpha as a key mediator of disease-related inflammation and tissue damage. While anti-TNF-alpha therapies are now widely used in the treatment of inflammatory arthritis, there are a number of patients taking systemic anti-TNF-alpha therapies who do not fully respond to those therapies and still have one or several affected joints. tgAAC94 is an AAV-based product containing the gene for the soluble TNF-alpha receptor protein. tgAAC94 is delivered directly to the affected joint where it should express the soluble TNF-alpha receptor protein locally and on a sustained basis.
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ORENCIA is a prescription medicine that is used to treat adults with moderate-to-severe rheumatoid arthritis (RA) who have not been helped enough by other medicines for RA. A doctor may consider treatment with ORENCIA because the patient's disease is still active even though they may have tried other treatments. ORENCIA can be used alone or with other agents. ORENCIA should not be taken with biologic medications for RA such as Enbrel®, Humira®, Remicade®, or Kineret®.
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The word arthritis means inflammation of the joint. Swelling, redness, heat and pain are the signs of inflammation. Rheumatism means disease marked by inflammation and pain in joints, muscles or fibrous tissue. Arthritis is generally used to cover most of the inflammatory diseases that affect the spine, muscles, tendons and the bones, as well as the joints.
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Rheumatoid arthritis affects over 2 million American adults, of which about two-thirds of them are women. The disease, characterized by pain, stiffness, swelling, and deformity can become debilitating. Within 5 years of diagnosis, a third of patients are no longer working, and within 10 years, half of the patients have substantial functional disability. RA can shorten life expectancy by 5-10 years.
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[One] autoimmune disorder, systemic lupus erythematosus, commonly known as lupus, is an arthritis-related condition causing fever, rash, and swelling of the joints. Lupus can have serious complications, including inflammation of the lungs, kidneys, brain, bone marrow, and the lining of the heart. Lupus affects about 500,000 to 1.5 million Americans and is most common in young women aged 15 to 40. Females are nine times more likely than males to develop the disease.
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There are over 100 types of arthritis, including osteoarthritis, rheumatoid arthritis, and gout. The word "arthritis" means "joint inflammation." Inflammation is one of the body's natural reactions to disease or injury, and includes swelling, pain, and stiffness. Inflammation that lasts for a very long time or recurs, as in arthritis, can lead to tissue damage.
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