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Archimedes: Archimedes Model
built 627 days ago
A: The most innovative and powerful feature of Archimedes is the use of differential equations to describe the progress of disease. For each disease there are one or more features that describe its progression. For example, the feature that describes coronary artery disease is the occlusion of coronary arteries. The differential equations calculate the progression of each feature; the occurrence of signs, symptoms and health outcomes as a function of the feature; and the effects of interventions on the disease's progression. The parameters of the differential equations are calibrated with actual data so that the outcomes of the diseases in the model match what is seen in reality. This includes not only matching the basic epidemiology of the disease (e.g., incidence, prevalence, morbidity and mortality rates) but ... the effects of treatments on the occurrence of symptoms and health outcomes.
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The Archimedes Model has virtual people with virtual physiologies who get virtual diseases, go to virtual doctors, get virtual tests and treatments and have virtual outcomes. These aspects of health care are found in few, if any, other models. Here is an example of the level of detail captured in the model:
Archimedes determines multiple assembly sequences for a product. Given a CAD model of the product, the program automatically finds part-to-part contacts, generates collision-free insertion motions, and chooses assembly order. The designer specifies a quality metric in terms of application-specific costs for standard assembly process steps, such as part insertion, fastening, and subassembly inversion. Archimedes considers thousands of combinations of ordering and operation choices in its search for the best assembly sequences, and ranks the valid sequences by the quality metric. Archimedes enables faster and more error-free generation of higher quality assembly sequences without physical prototypes. Design changes can be tested immediately for their effect on the valid and optimal assembly sequences.
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Archimedes was founded to improve the quality and efficiency of health care by using advanced mathematics and computing methods to build realistic simulation models of physiology, diseases and health care systems. Archimedes is funded by Kaiser Permanente and is intended to benefit health care worldwide. http://archimedesmodel.com
The Archimedes simulation model, named for the Greek mathematician and inventor, takes advantage of the latest advances in computing, software design and mathematical modeling. It differs from other models of diabetes in several important ways. It is a full simulation, with every person, every doctor and every piece of equipment being represented and interacting as they do in reality.
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Today, the Archimedes model can be used only by highly trained scientists who know its coding specifications. Every application is uniquely configured, making the model costly and time-consuming to use. With RWJF support, the ARCHeS platform will extend the power of the Archimedes model to more health policy and health care decision-makers, including Congress and federal agencies; medical specialty societies and nonprofit disease associations; government programs such as Medicare and Medicaid; insurers and health care provider networks; and others.
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