LYCOS RETRIEVER 
Antihemophilic Factor
built 187 days ago
Antihemophilic Factor (Recombinant) RecombinateTM is a glycoprotein synthesized by a genetically engineered Chinese Hamster Ovary (CHO) cell line. In culture the CHO cell line secretes recombinant antihemophilic factor (rAHF) into the cell culture medium. The rAHF is purified from the culture medium utilizing a series of chromatography columns. A key step in the purification process is an immunoaffinity chromatography methodology in which a purification matrix, prepared by immobilization of a monclonal antibody directed to factor VIII, is utilized to selectively isolate the rAHF in the medium. The synthesized rAHF produced by the CHO cells has the same biological effects as Antihemophilic Factor (Human) [AHF (Human)] and structurally has a similar combination of heterogenous heavy and light chains as found in AHF (Human).
Source:
The Antihemophilic Factor/VWF complex consists of two different noncovalently bound proteins. Factor VIII is an essential cofactor in activation of Factor X leading ultimately to formation of thrombin and fibrin. The VWF promotes platelet aggregation and platelet adhesion on damaged vascular endothelium; it ... serves as a stabilizing carrier protein for the procoagulant protein Factor VIII.
Source:
Some antihemophilic factor products are derived from human plasma, and there is a small risk that these products may contain certain types of virus or bacteria. All products are processed to kill most viruses and bacteria. If you have questions concerning the risk of viral infections, discuss them with your prescriber or health care professional. If you are a newly diagnosed hemophiliac, you should have a hepatitis A and B vaccination.
If you need to have any type of surgery, tell the surgeon ahead of time that you are using antihemophilic factor (factor VIII). You may need to stop using the medicine for a short time.
Source:
This study investigated, by written survey, the perceived impact of recent technological changes on the American plasma derivative industry as they affected its two major products, serum albumin and antihemophilic factor (AHF). Those surveyed included product manufacturers, distributors, researchers and end-users.
Source:
MORE ABOUT
Antihemophilic Factor