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Antidepressants: Taking
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A combination strategy involves adding one or more additional antidepressants, usually from different classes so as to have a diverse neurochemical effect. Although this may be used in clinical practice, there is little evidence for the relative efficacy or adverse effects of this strategy.[75]
Tricyclic antidepressants. Amoxepine (not marketed by brand, generic available), although a tricyclic antidepressant rather than a neuroleptic (major tranquilizer), displays some of the more serious effects of the neuroleptics, including tardive dyskinesias (drug induced involuntary movements) and neuroleptic malignant syndrome, a potentially fatal syndrome whose symptoms include high fever, altered mental status, irregular pulse or blood pressure, and changes in heart rate. These adverse effects have not been reported with other tricyclic antidepressants.
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To be sure, many of the millions of people worldwide who take antidepressants experience no withdrawal symptoms when they stop. But some studies suggest that one in every 10 have some symptoms and one in 20 suffer significant distress, says Dr. Jerrold Rosenbaum, chief of psychiatry at Massachusetts General
ScienceDaily: Your source for the latest research news 
and science breakthroughs -- updated daily Unfortunately for women, the alcohol use remained higher whether those experiencing depression took antidepressants or not. The numbers are telling: 179 drinks per year for non-depressed women, 235 drinks for depressed women not using antidepressants, and 264 drinks for depressed women who used antidepressants
Zoloft is currently the most prescribed antidepressant for nursing mothers who aren’t already on other antidepressants (Pharmacotherapy 2005 Mar;25(3):411-25). It has become a popular antidepressant for nursing mothers because there have been no reported adverse affects on the nursing infant despite its frequent use.
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Each class of antidepressants works in a different way and has a broadly characteristic range of common side-effects. The most recent antidepressants are generally regarded as being more tolerable and less likely to cause death in case of overdose.
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