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Angioedema
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Angioedema is an abrupt swelling of the skin, mucous membrane, or both including respiratory and gastrointestinal tracts. This study aimed to report an experience of angioedema in a university hospital with respect to etiologies, clinical features, treatment, and outcome. One hundred and five patients were enrolled. About half had angioedema without urticaria. The common sites of involvement were periorbital area and lips. Forty five patients (49%) had systemic symptoms.
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INTRODUCTION — Angioedema is self-limited, localized swelling of the skin, which results from extravasation of fluid into interstitial tissues. Angioedema affects the skin and mucosal tissues of the face, lips, mouth, and throat, larynx, extremities, and genitalia, often in an asymmetric pattern. Bowel wall involvement presents as colicky abdominal pain. Angioedema may occur in isolation, accompanied by urticaria, or as a component of anaphylaxis.
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Angioedema refers to swelling that occurs in the tissue just below the surface of the skin, most often around the lips and eyes. It generally results from an allergic reaction to either a food or medication. More rarely, it may be a sign of an underlying condition such as leukemia or Hodgkin's disease. In an allergic reaction, the body produces histamine, which causes blood vessels to swell. There are two basic types of angioedema:
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Angioedema occurs in around 1 in 3 people with hives. It is caused by similar swelling deeper in the tissues. Angioedema is not always itchy and can sometimes be painful. Sometimes it can occur on its own. As well as in infection and allergy, angioedema is ... seen in two other situations. Around 1 in 100 people taking heart/blood pressure medicines called ACE (Angiotensin Converting Enzyme) inhibitors will develop angioedema.
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Angioedema is characterized by painless, nonpruritic, nonpitting, and well-circumscribed areas of edema due to increased vascular permeability. Angioedema is most apparent in the head and neck, including the [F]ace, lips, floor of the mouth, tongue, and larynx, but edema may involve any portion of the body. In advanced cases, angioedema progresses to complete airway obstruction and death caused by laryngeal edema. Angioedema may involve the gastrointestinal tract, leading to intestinal wall edema, which results in symptoms such as colicky abdominal pain, nausea, vomiting, and diarrhea. (To learn more click here)
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Angioedema and urticaria should be viewed as varying manifestations of the same pathologic process. Postcapillary venule inflammation results in fluid leakage and edema in both conditions. However, angioedema involves vessels in the layers of the skin below the dermis, while urticaria is localized superficial to the dermis. This results in varying clinical presentations.
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Angioedema