LYCOS RETRIEVER 
Angioedema: Swellings
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Angioedema is a condition characterized by swelling and the formation of welts (raised marks) on the skin. It is similar to hives, except the welts are larger and form at a deeper layer in the skin. This causes swelling of the skin that usually affects the face near the eyes and mouth, as well as the hands and feet. However, swelling can ... occur inside the throat, which can cause difficulty breathing.
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Angioedema is a swelling similar to urticaria (hives), but the swelling is beneath the skin rather than on the surface. The swellings are called welts. The welts usually occur around the eyes and lips. They may ... be found on the hands, feet, and throat. Angioedema can result from certain allergies.
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CLINICAL FEATURES — Angioedema generally develops over minutes to hours and resolves in 24 to 48 hours. The skin is either normal in color or erythematous, and pruritis is usually absent, unless the angioedema is associated with urticarial lesions (which are intensely pruritic). Pain and warmth are variably present. Angioedema resolves without leaving residual markings on the skin, unless there has been trauma induced by rubbing or scratching. Urticaria is presented elsewhere. (See "Etiology and diagnosis of urticaria").
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Angioedema is similar to hives or wheals, but the lesions are much bigger in size and form at a deeper layer of the skin. Typically, the skin of the face, around the mouth, the mouth’s mucosa as well as the tongue and sometimes even the throat swell up over a period of few minutes to several hours. The swelling may be accompanied by itchiness typically in the hands but can be elsewhere in the body. Sometimes there may ... be slight decreased sensation in the affected areas due to nerve compression.
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Angioedema is characterized by subcutaneous edema resulting from increased vascular permeability, dilation of venules and capillaries and separation of collagen bundles. This is in distinction to urticaria which is limited to the superficial dermis. A history of atopy can be elicited in 15% patients.
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Angioedema is associated with little or no pruritus but it is described as painful or burning [3] Angioedema generally lasts 12-48h and occurs in 40% patients with urticaria. [3] It commonly involves the lips, eye lids, face, extremeties and genitalia in an asymmetrical manner [4],[5] Laryngeal swelling is rare when angioedema is associated with urticaria, but it can occur with C1 inhibitor deficiency, angioedema caused by angiotensin converting enzyme (ACE) inhibitors or anaphylaxis [3],[4] Angioedema can ... involve the gastro intestinal tract, and cause abdominal pain, nausea, vomiting and diarrhea. Vantroyen et al. reported a case of angioedema in a 65-year-old woman with recurrent acute abdomen and ascites, who had undergone two negative surgical interventions before establishing the diagnosis [6] Angioedema without urticaria occur in underlying complement disorder and laryngeal edema is common and a major cause of death.
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