LYCOS RETRIEVER 
Allopurinol
built 188 days ago
Allopurinol-induced hepatotoxicity may ... be a hypersensitivity reaction to the drug. A generalized hypersensitivity vasculitis has rarely led to irreversible hepatotoxicity and death. The frequency of allopurinol-induced hypersensitivity reactions may be increased in patients with decreased renal function who receive allopurinol and a thiazide diuretic concomitantly. Allopurinol should usually not be administered to patients who have previously shown hypersensitivity to it or who have had a serious reaction to the drug.
Source:
Allopurinol is a structural isomer of hypoxanthine (a naturally occurring purine in the body) and acts to inhibit xanthine oxidase. This enzyme is responsible for the successive oxidation of hypoxanthine and xanthine resulting in the production of uric acid, the product of human purine metabolism.[1] In addition to blocking uric acid production, inhibition of xanthine oxidase causes an increase in hypoxanthine and xanthine, which are converted to closely related purine ribotides adenosine and guanosine monophosphates. Increased levels of these ribotides causes feedback inhibition of amidophosphoribosyl transferase, the first and rate-limiting enzyme of purine biosynthesis. Allopurinol therefore decreases both uric acid formation and purine synthesis.
Source:
Allopurinol may ... have some use in the treatment of such infections as Leishmaniasis and Trypanosomiasis. What are allopurinol tablets It may take several months or longer before you feel the full benefit of allopurinol. There were increased numbers of dead fetuses in dams given 100 mg/kg Allopurinol but not in those given 50 mg/kg. Drug information contained herein may be time sensitive. Long term high dose allopurinol was taken by 47 patients, long term low dose by 48 and recent low dose by 72. allopurinol Images
Source:
Allopurinol can prolong the effects of blood thinners such as warfarin (Coumadin) and put patients at risk for bleeding. It can ... increase chances of low blood sugar with chlorpropamide (Diabinese) and nerve toxicity with vidarabine. Allopurinol can decrease breakdown of azathioprine (Imuran), mercaptopurine (6-MP), cyclosporine (Neoral, Sandimmune) and theophylline (Theo-Dur, Theolair, Theo- 24) by the liver, increasing blood levels and side effects. Doses of azathioprine and mercaptopurine need to be reduced when they are used together with allopurinol. Mercaptopurine can be substituted for thioguanine (6-TG) to avoid this interaction altogether.
Source:
Allopurinol is used for the therapy of canine leishmaniasis in Europe and it is currently the main treatment for this disease in Israel. Allopurinol treatment is oral, inexpensive and can be prescribed by the attending veterinarian and administered by the owners of the dog at home. This study was designed to assess the clinical and parasitological efficacy of allopurinol in dogs with visceral leishmaniasis (VL). Five dogs with naturally-occurring VL were treated with 20 mg/kg of allopurinol once daily for 8 months. The dogs were physically examined and tested pre- and during treatment. Testing included: the determination of serum anti-leishmanial antibody titers by ELISA, recording of globulin levels and albumin/globulin ratio, evaluation of the parasitological status by culture of splene and lymph node aspirates, xenodiagnosis and the determination of the infectivity to Lutzomyia longipalpis sand flies.
Source:
Allopurinol is an enzyme blocker that lowers high levels of uric acid in your body by decreasing the amount produced. It is used to treat gout and certain types of kidney stones. This drug is ... used to prevent high uric acid levels in patients who receive cancer chemotherapy. Cancer cells that are destroyed with therapy release large amounts of uric acid into the bloodstream. This medicine works by causing less uric acid to be produced by the body. Allopurinol will not relieve a gout attack that has already started.
Source:
MORE ABOUT
Allopurinol