LYCOS RETRIEVER 
Acyclovir: Valacyclovir
built 614 days ago
In continuous ambulatory peritoneal dialysis (CAPD) patients, Acyclovir / Aciclovir-induced neurotoxicity is reported to be associated with high serum drug levels even when following the recommended reduced doses for this renal failure population. In view of the high oral bioavailability of valAcyclovir / Aciclovir (the L-valyl ester of Acyclovir / Aciclovir) the risk of neurotoxicity becomes more prominent. The present study was conducted in 12 CAPD patients who were administered a single oral dose of 500 mg valAcyclovir / Aciclovir. Acyclovir / Aciclovir was analyzed by high-performance liquid chromatography. Relative pharmacokinetic parameters were estimated based on Acyclovir / Aciclovir concentrations at 8, 12 and 24 h post-dose. High inter-patient variations were observed with Acyclovir / Aciclovir apparent total clearance 7.238 +/- 4 l/h and half-life (T1/2) 22.27 +/- 16.82 h. However, dosage simulations confirmed supratherapeutic Acyclovir / Aciclovir concentrations for all participants when following the recommended dose of 1,000 mg valAcyclovir / Aciclovir/24 h for varicella zoster infections.
Source:
Acyclovir is best for people who have few and or mild breakouts. Valtrex is best for people who suffer from severe or frequent breakouts. Please remember no matter what medication you might be taking, none of them prevent the spread of herpes.
Source:
Before beginning Acyclovir therapy, it is important to consider all the risks and benefits. Talk to your doctor if any of the following considerations apply to you. Tell your doctor if you have any allergies such as preservatives, dyes, sulfites, or specific foods. You should ... tell your doctor if you’ve ever had a reaction to ganciclovir, valAcyclovir, or Acyclovir. Tell your doctor if you are pregnant or planning to become pregnant. There are not tests on the safety of Acyclovir with pregnancy among humans.
Source:
Allergies - Tell your doctor if you have ever had any unusual or allergic reaction to Acyclovir, ganciclovir, or valAcyclovir. Also tell your health care professional if you are allergic to any other substances, such as foods, sulfites or other preservatives, or dyes.
Source:
Acyclovir is used to treat herpes virus infections such as oral herpes, genital herpes, shingles, herpes simplex, and chicken pox. Acyclovir interferes with the activity of enzymes needed for the replication of viral DNA in cells. By preventing the multiplication, the herpes virus cannot multiply as easily. The FDA approved the use of acyclovir in 1984. Another option is valacyclovir.
Source:
ValAcyclovir / Aciclovir is an oral prodrug of the antiherpetic agent Acyclovir / Aciclovir. An enzyme that hydrolyzes valAcyclovir / Aciclovir to Acyclovir / Aciclovir, valAcyclovir / Aciclovir hydrolase (VACVase), was purified from rat liver and characterized. VACVase was a basic (pI 9.4) protein associated with mitochondria. It was monomeric and had a molecular mass of 29 kDa. Amino acid sequences of six VACVase peptides, including its NH2 terminus (13 amino acids) and accounting for approximately 20% of its complete sequence, were not found in the SwissProt protein data base. VACVase hydrolyzed other amino acid esters of Acyclovir / Aciclovir in addition to valAcyclovir / Aciclovir (kcat/Km = 58 mM-1 s-1), with a preference for the L-alanyl (kcat/Km = 226 mM-1 s-1) and L-methionyl (kcat/Km = 200 mM-1 s-1) esters.
Source:
MORE ABOUT
Valacyclovir