The usual starting dose of Zoloft is 25-50 mg per day, up to a maximum of 200 mg per day. Since Zoloft stays in your body for 24 hours, doses should be taken at the same time every day. Do not take double doses of Zoloft, and ask your doctor what to do about missed doses. Dosage should be increased at minimum intervals of a week, and stopped slowly according to your doctor's advice. Zoloft should not be abruptly started or stopped.