The most common side effects with Agenerase are related to the stomach-intestinal system, as with other protease inhibitors. These include nausea, abdominal pain or discomfort, vomiting and diarrhea *. Other common side effects include rash * and numbness or tingling in or around the mouth *. Other reported side effects include numbness or tingling in the feet or hands or both, altered taste, fatigue, headache and depression or other mood disorders. In the original studies approximately 15% of patients taking Agenerase plus Retrovir and Epivir discontinued due to adverse events, due to either stomach/intestine symptoms, rash or numbness or tingling.