Retinoblastoma is the most common intraocular tumor of childhood, but it remains a rare disease. Retinoblastoma occurs in one of 15,000 to 20,000 live births (1). Approximately 200 new cases a year are diagnosed in the United States. The disease presents in infancy or early childhood, with the majority of cases diagnosed before the age of 4 years (2). The disease rarely occurs in older children or in adulthood. Unilateral disease occurs in approximately two thirds of all patients, whereas bilateral retinoblastoma comprises approximately one third of the total (2).