SIGNS AND SYMPTOMS — Cystitis is inflammation of the mucosal surface of the bladder and/or ureters. Patients may experience urgency, frequent urination of small volumes, and a painful burning sensation with urination. Suprapubic pain is common; ... flank or back pain should raise the possibility of upper urinary tract disease. In men, bladder spasms often produce severe referred pain in the glans penis. Pain or lesions in the external genitalia can also be associated with herpetic disease or mucosal candidal infection. Pain or lesions in the external genitalia can also be associated with herpetic disease or mucosal candidal infection.