Liver cancer is the fifth most common cancer worldwide. Approximately 500,000 cases of liver cancer are diagnosed each year and it is the third cause of cancer-related deaths. Hepatocellular carcinoma (HCC), the most common form of liver cancer, occurs more often in males than females and is most common in people over 50 years of age. The reported prognosis for advanced liver cancer is poor with most patients dying within a year regardless of the treatment they receive. Liver cancer represents a significant unmet medical need.