Acyclovir is For Herpes Zoster 800 mg every 4 hours orally, 5 times daily for 7 to 10 days. For Genital Herpes Initial Genital Herpes - 200 mg every 4 hours, 5 times daily for 10 days. Chronic Suppressive Therapy for Recurrent Disease - 400 mg 2 times daily for up to 12 months, followed by re-evaluation. Alternative regimens have included doses ranging from 200 mg 3 times daily to 200 mg 5 times daily.