The Fantastic Four comic was the first Marvel superhero comic, one of the key events that historians point to as marking the beginning of the Silver Age of Comics. From the first one hundred issues of this comic have come some of the most memorable characters and supporting cast, many of which have formed the foundation of the Marvel Comics mythology. Memorable and celebrated characters such as Doctor Doom, the Watcher, Galactus, the Silver Surfer, the Inhumans, the Skrulls, the Kree, the Black Panther, and Annihilus were all created by Stan Lee and Jack Kirby as supporting characters or adversaries in the Fantastic Four. Stan Lee's characteristic over-the-top billing of the book as "The World's Greatest Comic Magazine" was, perhaps, a self-fulfilling prophecy. Whether or not the series was the best selling at the time, it certainly felt like the "greatest". In many ways, this book, along with The Amazing Spider-Man, set the tone for the enduring Marvel Universe.