One of the major functions of The Extracorporeal Life Support Organization (ELSO), is to maintain a Registry comprised of all known cases in which ECLS was performed. Over 170 centers from around the world have contributed data to the Registry. Currently, there are over 35,000 cases in the Registry including over 24,000 newborns, 7,000 children, and 2,000 adults with respiratory and cardiac failure. These data are used by the individual centers for quality assurance purposes and for clinical decision making regarding the use of ECLS. Aggregate data are evaluated to enhance extracorporeal support technology and to advance the technique of ECLS. All data are confidential and have no related patient identifiers.