Set was the leader of all the ghouls in Necropolis, except for the underground ghouls who lived in the sewers. Set was annoyed at the Super Mutant presence in Necropolis and would try to recruit the Vault Dweller to take care of the problem. He is not mentioned in the Vault Dweller's memoirs, but the Vault Dweller did kill the super mutants, which led to the slaughter of everyone in Necropolis, including Set himself.